Quantitative analysis of late gadolinium enhancement in hypertrophic cardiomyopathy

Myocardial fibrosis delineation in late gadolinium enhancement images of Hypertrophic Cardiomyopathy patients using deep learning methods

Introduction: Accurate delineation of myocardial fibrosis in Late Gadolinium Enhancement on Cardiac Magnetic Resonance (LGE-CMR) has a crucial role in the assessment and risk stratification of HCM patients. As this is time-consuming and requires expertise, automation can be essential in accelerating this process. This study aims to use Unet-based deep learning methods to automate the mentioned ...

High Sensitivity of Late Gadolinium Enhancement for Predicting Microscopic Myocardial Scarring in Biopsied Specimens in Hypertrophic Cardiomyopathy

BACKGROUND Myocardial scarring can be assessed by cardiac magnetic resonance imaging with late gadolinium enhancement and by endomyocardial biopsy. However, accuracy of late gadolinium enhancement for predicting microscopic myocardial scarring in biopsied specimens remains unknown in hypertrophic cardiomyopathy. We investigated whether late gadolinium enhancement in the whole heart reflects mic...

Quantitative of myocardial extracellular volume fraction improves characterization of fibrotic burden in patients with apical hypertrophic cardiomyopathy beyond visual assessment with late gadolinium enhancement

Background Apical hypertrophic cardiomyopathy (APH), a variant of hypertrophic cardiomyopathy, is generally considered to have a benign clinical course, with localized hypertrophy and evidence of myofibril disarray and fibrosis at the apex alone. However, traditional late gadolinium enhancement (LGE) techniques are not sensitive enough to detect subclinical apical fibrosis. Accordingly, we hypo...

Improved prediction of adverse events in hypertrophic cardiomyopathy with quantitative late gadolinium enhancement and myocardial strain

The extent of late gadolinium enhancement can be assessed fast and reproducible using semi-quantitative method in patients with hypertrophic cardiomyopathy

Background In hypertrophic cardiomyopathy (HCM) assessment of late gadolinium enhancement (LGE) is increasingly important as LGE has been demonstrated to be an adverse prognosticator. Manual delineation of LGE after visual assessment is labour-intensive. Automatic quantification is limited by its dependence on signal/noise ratio and varying definition of LGE. Our aim is to assess inter-individu...

Prognostic value of late gadolinium enhancement cardiac magnetic resonance in hypertrophic cardiomyopathy: a meta-analysis

Background Contrast-enhanced cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) has emerged as an in vivo marker of myocardial fibrosis, although its significance in identifying high risk hypertrophic cardiomyopathy (HCM) patients remains unresolved. Previous meta-analyses have included studies with data involving overlapping patient populations, thus confounding eff...